Injectafer and Feraheme are both brand-name drugs. However, some people can experienceside effectsfor much longer - days, months, or indefinitely. Side effects are uncomfortable reactions to medications or drugs. Hypophosphatemia has been reported in people using Injectafer after the drug was released onto the market. In the second group, some people switched from taking iron by mouth to taking Injectafer. VenAccess is a trademark of Vifor (International) Inc. Switzerland. But its only approved for use in people with CKD who may or may not need dialysis. Clinical trials showed that Injectafer is effective in increasing hemoglobin levels in people with iron deficiency anemia (IDA). Injectafer and Feraheme have different approved uses, but theyre both used to treat IDA in certain adults. Understanding what thoseside effectsare can lead to a strategy to prevent them. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. If you have questions about side effects, call your doctor. This medication passes into breast milk. But you dont necessarily need to eat these foods unless your doctor tells you to do so. If needed, theyll recommend treatment, including certain medications. No, you most likely wont take Injectafer long term. What to Expect When You Get Your Whole Genome Sequenced, DNA Data Can Help You Understand Ehlers-Danlos Syndrome (EDS). It will take about three weeks to feel the effects but your fatigue will disappear and you will feel like a new person. stream This way, if you have an allergic reaction to Injectafer, your healthcare professional can treat your reaction. Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. As a result, you may not make as much EPO as usual. Injectafer and Venofer have different approved uses, but theyre both used to treat IDA in people with CKD. For more information about Injectafers approved uses, see the section Injectafer uses below. Cholesterolmedication may reduce the risk of a stroke but it can decrease the quality of life for some people but causingweight gain, dizziness, nausea, and musclepain. (A generic drug is an exact copy of the active drug in a brand-name medication.). And this could lead to weight gain, if they increase their food intake. These lists contain examples of serious side effects that can occur with Injectafer, with Venofer, or with both drugs (when taken individually). In clinical studies, Injectafer was effective in treating IDA in adults who either didnt improve with or had side effects from taking iron by mouth. While this may seem like it would be out of a persons body quickly, the rate of it being broken down is much slower afterward. You should always consult your doctor or another healthcare professional before taking any medication. One study of just under 5000 HRT users found that 43% were affected. There may be risks to the mother and fetus associated with untreated IDA in pregnancy. Serious side effects, which are explained in more detail below in Side effect details, include: You may wonder how often certain side effects occur with this drug. This is a sudden response affecting the entire body, which sometimes happens to people who are allergic to peanuts or beestings. Venofer pregnancy and breastfeeding warnings. Allergic reaction As with most drugs, some people can have an allergic reaction after taking Injectafer. Injectafer isnt known to interact with any other medications, herbs, supplements, or foods. TheNational Instituteof Health (NIH) and the U.S.Food and Drug Administration(FDA) monitor the side effectsof new and approved medications to ensure safety. With anemia, you have a low level of red blood cells (RBCs) in your body. Many people using this medication do not have serious side effects. If you are allergic to Venofer; any part of this medicine; or any other drugs, foods, or substances. The oral form of the drug, called sucroferric oxyhydroxide and used . Weight changes may be due to symptoms of anemia improving. wAd**CgI%"nn{Oa[q{r5 Dizziness. Do not use Injectafer in people with a history of hypersensitivity reactions to Injectafer or any components of the drug product. . As described just above in the Allergic reaction section, some people may have an allergic reaction after getting a dose of Injectafer. Venofer treatment may be repeated if iron deficiency reoccurs. Its given by either intravenous (IV) infusion or slow IV injection. Keep all regular medical and laboratory appointments. Examples of thisinclude: Not allside effectslast forever. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Venofer only for the indication prescribed. What to know about iron deficiency anemia, took oral iron treatment and didnt have improvement in their IDA or had side effects that couldnt be managed, or, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, have a medical condition that affects their bodys ability to absorb phosphorus, take medications that affect how well their, ferrous sulfate (Fer-Iron, Slow-FE, Feosol), people who took Injectafer had their hemoglobin level increase by an average of 1.1 grams per deciliter (g/dL), people who took Venofer had their hemoglobin increase by an average of 0.9 g/dL. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. However, since peoples bodies react so differently to drugs, they often have to change their stance on certaindrugs. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Dilute Venofer in a maximum of 250 mL of 0.9% NaCl. If you have questions about the best diet for you during Injectafer treatment, talk with your doctor. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Below are examples of these side effects. If youre interested in finding an alternative to Injectafer, talk with your doctor. All of the people took iron by mouth for 2 weeks. And theyll recommend how soon after starting the drug you need to have this level checked. They have been a god send. But if they become more severe or dont go away, talk with your doctor or pharmacist. This site is intended for use only by US patients. However, since peoples bodies react so differently to drugs, they often have to change their stance on certain drugs. You may need extra iron because of blood loss during kidney dialysis. fluid retention, especially in your arms, legs, or feet, people who took Feraheme had their hemoglobin level increase, on average, by 1.38 grams per deciliter (g/dL), people who took ferric carboxymaltose had their hemoglobin level increase, on average, by 1.63 g/dL, having strange cravings to eat items that arent food, such as ice, people who took Injectafer had their hemoglobin level increase, on average, by 1.6 grams per deciliter (g/dL), people who kept taking iron by mouth had their hemoglobin level increase, on average, by 0.8 g/dL, people who took Injectafer had their hemoglobin level increase, on average, by 2.9 g/dL, people who took the other intravenous iron product had their hemoglobin level increase, on average, by 2.2 g/dL, people who took Injectafer had their hemoglobin level increase by an average of 1.1 g/dL, people who took Venofer had their hemoglobin level increase by an average of 0.9 g/dL, cannot tolerate or have shown a poor response to oral iron, or, have been diagnosed with chronic kidney disease (CKD) that is non-dialysis dependent. For people weighing less than 50 kg, administer Injectafer in two doses of 15 mg/kg of body weight, at least 7 days apart. Theyll do this by checking certain blood tests. In clinical trials, serious allergic reactions occurred in 0.1% to 1.5% of people taking Injectafer. However, not treating iron deficiency anemia during pregnancy may cause complications such as premature birth or low birth weight. With IDA, you have anemia (low red blood cell level) thats due to not having enough iron in your body. It can be given as a slow injection over 2 to 5 minutes or as an infusion. Potentialside effectsthat are usually mild may include, but are not limitedto: Theseside effectsmay not impact life too much and may only be temporary. Injectafer isnt available in a generic form. They can recommend if this is safe for you to do. You may report side effects to the FDA at 1-800-332-1088. The researchers found that compared with their hemoglobin level before the study: But the actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. This medication is given by injection into a vein as directed by your doctor. If you have more questions about how Injectafer will affect your anemia, talk with your doctor. A lack of iron can lead to iron deficiency anaemia if left untreated. Injectafer contains the active drug ferric carboxymaltose, while Feraheme contains the active drug ferumoxytol. Hes an expert in genetic testing, genetic analysis, andprecision medicine. These are not all of the side effects that may occur. The time it takes to infuse Venofer (iron sucrose) depends on your age, if you're on dialysis, and the type of dialysis you need. 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Generic name: iron sucrose (injection) [EYE-urn-SOO-krose] But for other people, their IDA returns after treatment with Injectafer. WARNINGS/CAUTIONS: Serious hypersensitivity reactions, including anaphylactic-type reactions (itching, hives, swelling, wheezing, difficulty breathing, fainting and/or other allergy symptoms), some of which have been life threatening and fatal, have happened in patients receiving Venofer. Does Venofer Vial interact with other drugs you are taking? Is the ketogenic diet right for autoimmune conditions? Feraheme also comes as a liquid thats given by IV infusion. Venofer (iron sucrose) is given by injection into a vein as directed by your doctor. If you have iron deficiency anemia (IDA), consuming moderate amounts of alcohol may be safe, if your doctor tells you its OK. (With IDA, you have a low level of red blood cells thats caused by not having enough iron.). If you have iron deficiency anemia (IDA), there are certain foods you can eat that may help increase your iron levels. Nausea. What Is the Cost of Whole Genome Sequencing (WGS)? If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Keep all medications away from children and pets. But you kidneys need iron in order to make EPO. There have also been reports of serious allergic reactions to Venofer. Reblozyl is a brand-name prescription medication used to treat anemia in certain blood disorders. The signs and symptoms of anaphylaxis include dizziness or fainting, skin flushing and itchiness, difficulty breathing, rapid heart rate, low blood pressure and sudden anxiety. There are currently no generic forms of either drug. Some products that may interact with this drug include: vitamin products, other iron-containing products. Can poor sleep impact your weight loss goals? Injectafer is approved to treat iron deficiency anemia (IDA). Injectafer contains the active drug ferric carboxymaltose, while Venofer contains the active drug iron sucrose. In severe cases, it can cause asthma-like symptoms, such as wheezing and difficulty breathing. I was surprised too but the Dr said it definitely sounds like a reaction. It belongs to a class of medications called iron replacement products. Its caused by your body not having enough iron, which is needed to make hemoglobin. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Other side effects include: Common (may affect up to 1 in 10 users) Temporary taste changes (especially metallic taste) Low blood pressure or high blood pressure. After getting each dose of Injectafer, your healthcare professional will monitor you for at least 30 minutes. Side effects like nausea and low blood pressure are common with most iron infusions. Yes, in some cases it may. Hypophosphatemia seems to mostly occur in people who are already at risk for low phosphorus levels. These tests will help make sure Injectafer is working to treat your iron deficiency anemia (IDA). Upset stomach or throwing up. Iron infusion side effects vary depending on which form is being used. The study also didnt show if one treatment was worse than the other. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. Venofer Side Effects. Some people are simply allergic to an active ingredient in the medication, so the body responds undesirably. They can tell you about other medications that may work well for you. Does Venofer Vial interact with other medications? % This may be helped by giving the medication more slowly or at a lower dose. taste impairment. However, to be safe, tell your doctor or pharmacist about all prescription, over-the-counter, and other drugs you take before taking Injectafer. This is why family members often have the same issues with drugs as others in theirfamily. Injectafer can cause mild or serious side effects. However, side effects at the 150 mg dose may indicate that you might not . Procedure Details Its not known if Injectafer is safe to use during pregnancy. This website is intended for use by US healthcare professionals only. But the length of time that this may take varies from person to person. What is the latest research on the form of cancer Jimmy Carter has? Do not exceed 1,500 mg of iron per dosing course. experience severe side effects, please seek medical attention right away and notify the ordering physician. You may also need to monitor your blood pressure at home. These pregnancy-related problems include preterm delivery and low birth weight of your infant. You may wonder how Injectafer compares with other medications that are prescribed for similar uses. But for most people whove developed hypophosphatemia with Injectafer, the condition resolved within 3 months. Together, you and your doctor can discuss the benefits and risks of treatment options for anemia. Its FDA-approved to treat iron deficiency anemia (IDA) in adults. This includes people who: Usually, hypophosphatemia doesnt cause symptoms. As with all medications, the cost of Injectafer can vary. The researchers looked to see how well each drug worked to increase peoples hemoglobin level. reese0809 1 yr. ago. Throw away unused or expired drugs. The iron released by this drug does pass into human breast milk. Venofer injection contains iron sucrose, a form of the mineral iron. Hemoglobin is a protein thats found inside your red blood cells. (Hemoglobin is a protein thats found in your red blood cells.). A delayed reaction can occur in two different ways: It can happen hours or days after you receive a drug, or it can happen after a second (or later) dose of a drug. But call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. Orofer S 100 Injection 1 Injection in 1 Packet 286 301 5% off. weakness. Its possible to get rid of or reduce the severity ofside effects. (Hemoglobin is a protein thats found in red blood cells.). administered at your doctors office or an infusion center. An LSD comedown is when the mental and hallucinatory effects have worn . So the goal of anemia treatment is to increase your hemoglobin level back to a value thats within a normal range. Injectafer and Venofer are both brand-name drugs. But for other people, their anemia may come back after Injectafer treatment. Keep all drugs in a safe place. Once inside your body, ferric carboxymaltose releases iron into your system. Spacing your Injectafer doses out at least 7 days helps to reduce your risk of side effects. TheNational Instituteof Health (NIH) and the U.S. Food andDrug Administration(FDA) monitor theside effectsof new and approved medications to ensure safety. In the first group, some people continued taking iron by mouth, while other people took Injectafer. Phosphorus also helps your nerves function properly. In clinical studies, people who took Injectafer had their hemoglobin level improve as early as 35 days after receiving treatment. Keep out of reach of children. Answer by DrLact: About Venofer usage in lactation. I'm contemplating getting infusions again but I've always been a bit worried that they could cause issues in the long run. This allows them to manage any side effects that you may have following your dose. Venofer (iron sucrose injection, USP) Rx Only DESCRIPTION Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)-hydroxide in sucrose for intravenous use. Allergic reactions are most likely to occur within 30 minutes of receiving Venofer. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. Venofer may reduce the absorption of iron preparations taken by mouth. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. However, there has been a report of delayed allergic reaction in someone receiving a second dose of Injectafer. With a delayed reaction, your body reacts to a drug that youve been exposed to in the past without having a reaction. Injectafer can be exposed to temperatures between 59F to 86F (15C to 30F) for a short period of time. Do not start, stop, or change the dose of any drug without checking with your doctor. Both Injectafer and Feraheme belong to a class of medications known as iron replacement products. I hope you found answers and are feeling better now. For some people, it may be OK to continue taking a multivitamin that contains iron. While the side effects that occur during treatment with these drugs are increasingly well-cataloged, the long-term side effects that may result from receiving these drugs are only beginning to be studied. Common MRI side effects include dizziness, anxiety, headache, nausea, hearing loud noises, and feeling chilled or hot in the MRI scanner. WebMD does not provide medical advice, diagnosis or treatment. Properly discard this product when it is expired or no longer needed. With slow IV injection, the drug is given as a single, slow injection into your vein. Joint pain. Do not double the dose to catch up. Weight influences how fast medication breaks down in the body, so it also affects how longside effectswill last. Injectafer infusions are given over a period of at least 15 minutes. Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in adult and pediatric (2 years of age and older) patients with chronic kidney disease (CKD), and is administered only by or under the supervision of your healthcare provider. A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. All patients receiving Venofer require periodic blood tests to monitor the amount of iron in the blood. They can give you tips on how to deal with any side effects that may be bothersome. Not all possible drug interactions are listed here. The infusion concentration should not be less than 2 mg of Injectafer per mL of solution. Your doctor will recommend whether you should stop taking your multivitamin or any other supplements. You are encouraged to report side effects to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. chills difficulty with moving ear congestion or pain flushed, dry skin fruit-like breath odor increased hunger or thirst increased urination lack or loss of strength pain or redness at the injection site pale skin at the injection site runny nose, sneezing sore throat unexplained weight loss Rare Burning, dry, or itching eyes Its responsible for carrying oxygen throughout your body. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Other drugs may interact with iron sucrose, including prescription and over-the-counter medicines, vitamins, and herbal products. Talk with the doctor. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. And if you dont have an allergic reaction to your first dose of a drug, its typically safe to assume you wont have an allergic reaction to doses that follow. Symptoms of overdosage include drowsiness, mental confusion, dizziness, diarrhea and vomiting etc. You may also report side effects at https://www.fda.gov/medwatch. US residents can call their local poison control center at 1-800-222-1222. The rest of the people switched from taking iron by mouth to taking an iron product other than Injectafer thats given by IV. It's a more immediate treatment than supplements or dietary changes. This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. The Injectafer dosage your doctor prescribes will depend on your body weight. For reasons we dont fully understand, some peoples immune system gets over-activated when the drug enters their body. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. You may wonder how Injectafer compares with other medications that are prescribed for similar uses. If a person does not have an allergic response or any other unanticipated reactions, a doctor will administer the remaining iron. You should not receive Venofer if you have known allergies to iron sucrose. Always review your medical history with the treatingphysician. All rights reserved. Also tell them about any vitamins, herbs, and supplements you use. And babies born to those who took Injectafer during pregnancy didnt have any major congenital anomalies (also sometimes called birth defects). These side effects can range from being mild to severe. Low blood pressure. The drug helps increase your hemoglobin level back to a value thats within the normal range. On the other hand, some people may have a poor appetite that goes away when their anemia is treated. fruit-like breath odor increased hunger or thirst increased urination lack or loss of strength pain or redness at the injection site pale skin at the injection site runny nose, sneezing sore throat unexplained weight loss Rare Burning, dry, or itching eyes discharge or excessive tearing Your healthcare provider will watch you closely for 30 minutes after each dose. Dr. Colby is alsothe Founder of Sequencing.com and the authorofOutsmart Your Genes. Pain in your limbs. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Hemoglobin is a protein thats found in your RBCs. Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. * Feraheme has a boxed warning for this side effect. People who weigh less than 110 lb (about 50 kg) will receive two separate Injectafer doses of 15 mg/kg of body weight. Change in taste. Side effectsare uncomfortable reactions to medications or drugs.
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